A novel patient-derived cutaneous melanoma cell line reveals key features of metastatic melanoma.

ABSTRACT:

Introduction

Cutaneous melanoma (CM) is an aggressive form of skin cancer, with rising incidence and poor prognosis at advanced stages. While early-stage CM typically carries a favorable prognosis, a small subset of patients relapses and progresses to advanced disease, highlighting the need for a deeper understanding of CM biology. Here, we describe the establishment and characterization of a novel patient-derived primary cell line, MelT79, developed from a metastatic lesion of a patient initially diagnosed with stage IB CM, who unexpectedly progressed to advanced disease.

Methods

MelT79 was characterized by multicolor fluorescence in situ hybridization, high resolution comparative genomic hybridization, and targeted next-generation sequencing. Gene and protein expression we

SUBMITTER: Tomas A 

PROVIDER: S-EPMC12313697 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature