Lipidomic analyses reveal the dysregulation of oxidized fatty acids (OxFAs) and acyl-carnitines (CARs) in major depressive disorder: a case-control study.

ABSTRACT:

Background

Growing data indicated that individuals diagnosed with major depressive disorder (MDD) had widespread inflammation, oxidative stress, and metabolic dysregulation. The objective of our study was to detect alterations in lipids of individuals with MDD, with the ultimate aim of developing potential biomarkers that may contribute to the diagnosis and treatment of MDD.

Methods

The current study was a single-center cross-sectional case-control design. Serum samples were obtained from 107 individuals diagnosed with MDD and 97 healthy controls (HC) aged 18 to 60 years. Lipidomics analysis was performed using an Ultimate 3000 UHPLC system coupled with a Q-Exactive HF MS platform. All data were processed using the specialized online software Metaboanalyst 5.0.

Results

SUBMITTER: He L 

PROVIDER: S-EPMC12317606 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature