<i>Cdc42</i> defect reveals insights into microvilli organization and function in T cell immunity.

ABSTRACT: Microvilli on T cells differ from those on epithelial cells, exhibiting filopodia-like characteristics that facilitate the clustering of molecules essential for sensing and cell migration. Recently, they have also been recognized as the structures from which T cell immunological synaptosomes (TIS) are released. In this study, we examined a key determinant of microvilli organization during T cell development and explored the functional roles of these structures, particularly in relation to T cell behaviors. During thymocyte maturation, single-positive thymocytes were found to develop more and longer microvilli than double-positive thymocytes. However, the deletion or inhibition of Cdc42, a small Rho family protein, significantly reduced both the number and length of microvilli in single-pos

SUBMITTER: Soh WC 

PROVIDER: S-EPMC12318239 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature