Performance and workflow comparison of the VITEK MS PRIME and Bruker Biotyper MALDI-TOF MS systems.

ABSTRACT: Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) is widely used for rapid identification of bacteria and yeast in clinical labs. The VITEK MS PRIME ("PRIME") is the latest MALDI-TOF MS system from bioMérieux. This study evaluated PRIME's performance and workflow timing against the MALDI Biotyper CA System by Bruker ("Biotyper"). We compared a collection of 154 bacteria and yeast clinical isolates from various specimen types using three methods: Biotyper target with a toothpick, PRIME target with the PICKME nib, and PRIME target with a loop. Positive blood culture isolates were also analyzed using these methods, with high-experience (HEU, n = 300) and low-experience users (LEU, n = 50) after short (6-8 h) and routine (18-24 h) incubat

SUBMITTER: Bosserman RE 

PROVIDER: S-EPMC12345239 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature