Species-specific gene regulatory network rewiring mediated by the GATA-type regulator NsdD in <i>Aspergillus</i>.

ABSTRACT: The evolutionarily conserved GATA-type transcription factor (TF) NsdD regulates sexual and asexual development as well as secondary metabolism in various Aspergillus species. Despite its well-known multifunctionality, the mechanisms by which NsdD coordinates such diverse biological processes remain unclear. To address this gap, we have conducted network-based multiomics analyses in two distantly related species, Aspergillus nidulans and Aspergillus flavus. Transcriptomic profiling reveals that NsdD regulates gene expression in a cell type- and species-specific manner. The potential evolutionary conservation of NsdD was tested by a cross-complementation experiment in which the A. nidulans nsdD gene was introduced into the A. flavus ΔnsdD mutant. Thi

SUBMITTER: Moon H 

PROVIDER: S-EPMC12345274 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature