Genomic regions associated with bovine respiratory disease in pacific northwest Holstein cattle.

ABSTRACT:

Introduction

Bovine respiratory disease (BRD) is the leading natural cause of death in cattle. It is a multifactorial disease comprised of bacterial and viral pathogens. To aid in the reduction of BRD morbidity and mortality and the selection of cattle with reduced susceptibility, the objectives of this study were to identify loci, gene sets, positional candidate and leading-edge genes associated with or enriched for BRD in pre-weaned and post-weaned Holstein calves.

Methods

From a single dairy, 518 pre-weaned (0-60 days old) and 2,001 post-weaned (61-421 days old) Holstein heifers were treated for BRD and served as cases. All 3,655 pre-weaned healthy control calves remained in the herd for a minimum of 60 days, and 3,210 healthy post-weaned control calves remained in the he

SUBMITTER: Herrick AL 

PROVIDER: S-EPMC12350131 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature