Chemical Constituents from the Leaves of <i>Eruca sativa</i> (Rocket Salad) Exhibiting Dual Cardioprotective and Antiplatelet Activities.

ABSTRACT: Eruca sativa (rocket salad; arugula) is a well-known edible plant commonly used in salads and as a topping for pizza and pasta. In this study, one new cyclic thiocarbamate (1) and four new kaempferol glycosides (2-5), along with 15 known compounds (6-20), were isolated from leaves of E. sativa using chromatographic methods. The structures of all compounds were elucidated based on their HR-ESI-MS, ¹H and ¹³C NMR, and 2D NMR data. All isolates were evaluated for their cardioprotective and antiplatelet activities. Among them, compound 2 exhibited the most potent antioxidant activity in a DPPH assay. Further investigation revealed that compound 2 significantly reduced cellular ROS levels in H9c2 cardiomyocytes

SUBMITTER: Zheng R 

PROVIDER: S-EPMC12355429 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature