Type III Collagen Regulates Matrix Architecture and Mechanosensing during Wound Healing.

ABSTRACT: Postnatal cutaneous wound healing is characterized by development of a collagen-rich scar lacking the architecture and functional integrity of unwounded tissue. Directing cell behaviors to efficiently heal wounds while minimizing scar formation remains a major wound management goal. In this study, we demonstrate type III collagen (COL3) as a critical regulator of re-epithelialization and scar formation during healing of COL3-enriched, regenerative (Acomys), scar-permissive (CD-1 Mus and wild-type Col3^B6/B6 mice) and COL3-deficient, scar-promoting (Col3^F/F, a murine conditional knockdown model) cutaneous wound models. We define a scar-permissive fibrillar collagen architecture signature characterized by elongated and anisotropically aligned collagen fibers that is dose

SUBMITTER: Stewart DC 

PROVIDER: S-EPMC12359077 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature