The stealth effect from a medicinal chemist perspective: definition and updates.

ABSTRACT: In recent years, there has been a significant increase in literature on emerging nanotechnologies, including nanoparticles, nanorobots, and exosomes, for various therapeutic applications. Additionally, politically driven research initiatives aimed at accelerating COVID-19 vaccine development have further amplified interest in nanoparticles as drug delivery systems. This article provides a personal perspective on the scientific claims surrounding nanoparticles by: (i) analyzing the historical evolution of their terminology, (ii) reviewing the most cited publications in the field, and (iii) offering a professional assessment to guide the next-generation of medicinal chemists. A key aspect of this discussion is the stealth effect, which refers to the ability of nanoparticles to evade recognit

SUBMITTER: Fuoco D 

PROVIDER: S-EPMC12360436 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature