Restrictive versus Liberal Transfusion in Myocardial Infarction - A Patient-Level Meta-Analysis.

ABSTRACT:

Background

Clinical guidelines have concluded that there are insufficient data to provide recommendations for the hemoglobin threshold for the use of red cell transfusion in patients with acute myocardial infarction (MI) and anemia. After the recent publication of the Myocardial Infarction and Transfusion (MINT) trial, we performed an individual patient-level data meta-analysis to evaluate the effect of restrictive versus liberal blood transfusion strategies.

Methods

We conducted searches in major databases. Eligible trials randomly assigned patients with MI and anemia to either a restrictive (i.e., transfusion threshold of 7-8 g/dl) or liberal (i.e., transfusion threshold of 10 g/dl) red cell transfusion strategy. We used individual patient data from each trial. The primary

SUBMITTER: Carson JL 

PROVIDER: S-EPMC12367329 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature