Temporal trends of a cellular host response test for sepsis and a comparison with selected biomarkers of inflammation and infection.

ABSTRACT: Sepsis, a condition characterized by immune dysregulation, is the leading cause of in-hospital mortality and requires rapid treatment. Assessing immune dysregulation has been challenging. The IntelliSep Index (ISI), a novel biomarker which leverages microfluidic deformability cytometry to assess immune activation, has been evaluated as a test for Emergency Department use but it is unclear how the signal evolves as patient condition evolves. In a 47-patient cohort with hospital stays ≤ 14 days, ISI provided a good indicator of disease progression by blinded physician review. ISI trends correlated with clinical improvement over time. During the first 12 h following presentation, ISI was unaffected by antibiotic treatment initiated in the emergency department (ED). After this period however,

SUBMITTER: Berlinger MS 

PROVIDER: S-EPMC12368155 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature