Multimodal Inhibition of <i>Pectobacterium brasiliense</i> Virulence by the Citrus Flavanone Naringenin.

ABSTRACT: Naringenin, a flavanone from citrus, was studied for its ability to reduce virulence in Pectobacterium, a phytopathogen causing soft rot disease in crop plants. Naringenin downregulated quorum sensing (QS) and suppressed critical virulence determinants in Pectobacterium brasiliense Pb1692, including plant cell wall-degrading enzymes, bacterial motility, and biofilm formation, consequently reducing disease symptoms in two host plants. Molecular docking simulations revealed a plausible binding mode for naringenin within the QS protein ExpI, which were maintained during microsecond-long Molecular Dynamics simulations. These simulations provided atomic-scale insight into specific interactions and estimated binding free energies, supporting naringenin's QS inhibition mode of actio

SUBMITTER: Pun M 

PROVIDER: S-EPMC12371876 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature