Fas^lpr gene dosage tunes the extent of lymphoproliferation and T cell differentiation in lupus.

ABSTRACT: Sle1 and Fas^lpr are two lupus susceptibility loci that lead to manifestations of systemic lupus erythematosus. To evaluate the dosage effects of Fas^lpr in determining cellular and serological phenotypes associated with lupus, we developed a new C57BL/6 (B6) congenic lupus strain, B6.Sle1/Sle1.Fas^lpr/+ (Sle1^homo.lpr^het) and compared it with B6.Fas^lpr/lpr (lpr^homo), B6.Sle1/Sle1 (Sle1^homo), and B6.Sle1/Sle1.Fas^lpr/lpr (Sle1^homo.lpr^homo) strains. Whereas Sle1^homo.lpr^homo mice exhibited profound lymphoproliferation and early mortality, Sle1^homo.lpr^het mice had a lifespan comparable to B6 mice, with no evidence of splenomegaly or ly

SUBMITTER: Bohat R 

PROVIDER: S-EPMC12374782 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature