Genetic Loci Associated With Periodontitis: The FinnGen Study Based on National Health Registers.

ABSTRACT:

Aim

To perform a genome-wide association study (GWAS) for periodontitis in the FinnGen cohort, as genetic factors contribute to periodontitis.

Materials and methods

We included nearly 250,000 Finnish individuals who had visited a dentist in the public healthcare sector for a clinical oral examination. We designed three periodontitis phenotypes based on diagnosis and procedure codes and CPI indexes in national health registers.

Results

We identified 11 independent genetic loci associated with periodontitis, among which 6 were common and novel. A locus near the FST gene was associated with two phenotypes, whereas other lead SNPs were located near ARL15, MFHAS1, DEFB130A and APOE. Additionally, all phenotypes in the discovery and replication cohorts were associated with

SUBMITTER: Salminen A 

PROVIDER: S-EPMC12377943 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature