Clinical Features Associated With Periodontal Case Misclassification by an Active Matrix Metalloproteinase-8 Point-of-Care Oral Rinse Test.

ABSTRACT:

Background

The diagnostic performance of active matrix metalloproteinase-8 (aMMP-8) point-of-care oral rinse test (POC-ORT) for periodontitis needs to be improved because of its relatively low sensitivity. This study attempted to identify the clinical features associated with the misclassification of periodontal cases by the test.

Method

This work consisted of two cross-sectional diagnostic accuracy studies involving a representative cohort in Hong Kong, China, and a convenience sample of subjects in Shanghai, China. The outcomes of the aMMP-8 POC-ORT (index test) were compared to the case definitions of the 2017 World Workshop on the classification of periodontal health status (reference test). The analysis reports the diagnostic accuracy parameters, the Youden index and co

SUBMITTER: Bi M 

PROVIDER: S-EPMC12377944 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature