Tracing the evolutionary dynamics of carbapenem-resistant Escherichia coli in recurrent and multi-site infections.

ABSTRACT: Carbapenem-resistant Escherichia coli (CREC) can cause persistent or multi-site infections, leading to significant clinical challenges due to the limited availability of effective antibiotics. However, the within-host evolution of CREC and its impact on infection patterns remain poorly understood. This study aims to characterize CREC isolates from patients with recurrent or multi-site infections to elucidate the relationship between bacterial adaptation within the host and infection dynamics, thereby addressing a critical gap in our understanding of CREC pathogenesis. Genotypic analysis, including Nanopore whole-genome sequencing, and phenotypic comparisons were performed on CREC isolates from individual patients. Pulsed-field gel electrophoresis (PFGE) patterns revealed that 18 patients w

SUBMITTER: Cheng YY 

PROVIDER: S-EPMC12379366 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature