Assessing local structural perturbations in proteins.

ABSTRACT:

Background

Protein structure research often deals with the comparison of two or more structures of the same protein, for instance when handling alternative structure models for the same protein, point mutants, molecule movements, structure predictions, etc. Often the difference between structures is small, restricted to a local neighborhood, and buried in structural "noise" due to trivial differences resulting from experimental artifacts. In such cases, whole-structure comparisons by means of structure superposition may be unsatisfactory and researchers have to perform a tedious process of manually superposing different segments individually and/or use different frames of reference, chosen roughly by educated guessing.

Results

We have developed an algorithm to compare local

SUBMITTER: Lema MA 

PROVIDER: S-EPMC1239910 | biostudies-literature | 2005 Sep

REPOSITORIES: biostudies-literature