Site-Selective Electrochemical Intramolecular C(sp²)-H Selenylation for Dibenzoselenophene Synthesis.

ABSTRACT: We report a robust and eco-conscious electrosynthetic protocol for efficiently constructing structurally diverse and biologically relevant dibenzoselenophenes. This transformation proceeds via electrochemical intramolecular C-H activation of bis(biaryl) diselenides, employing LiClO₄ as a green electrolyte and tetrabutylammonium bromide as an additive, conducted in DMSO at 70 °C under a constant current of 10 mA using Pt/Pt electrodes. The newly developed method offers several notable advantages, including mild and energy-efficient conditions, transition-metal-free catalysis, short reaction times, high to excellent yields, broad substrate tolerance, scalability to gram-scale synthesis, operational simplicity, and environmental friendliness.

SUBMITTER: Karmakar I 

PROVIDER: S-EPMC12400415 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature