Adverse pregnancy outcomes and long-term risk of stroke: a Swedish nationwide co-sibling study.

ABSTRACT:

Background and aims

The lifelong risk of stroke following adverse pregnancy outcomes, and potential causality, are unknown. This study examined five major adverse pregnancy outcomes and long-term risk of stroke in a large population-based cohort.

Methods

A national cohort study was conducted of all 2 201 393 women with a singleton delivery in Sweden during 1973-2015, followed up for stroke through 2018. Cox regression was used to determine hazard ratios (HRs) for stroke associated with preterm delivery, small for gestational age, preeclampsia, other hypertensive disorders, and gestational diabetes, adjusting for other maternal factors. Co-sibling analyses assessed for potential confounding by shared familial (genetic or environmental) factors.

Results

In 48 million pe

SUBMITTER: Crump C 

PROVIDER: S-EPMC12401571 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature