Development of a new TNM staging system for poorly differentiated thyroid carcinoma: a multicenter cohort study.

ABSTRACT:

Objective

Poorly differentiated thyroid cancer (PDTC) is a rare, heterogeneous carcinoma from follicular cells, characterized by poor differentiation, aggressive spread, and poor prognosis. Currently, there is no specific staging system for PDTC. This study aimed to develop a new TNM staging system tailored to PDTC for improved disease management.

Methods

A new TNM staging system was designed and internally validated using data from the US SEER database (2004-2016) on PDTC cases. External validation was performed using data from four major institutions in China. Prognostic factors influencing cancer-specific survival (CSS) were identified through Cox regression analyses. Patients were stratified into subgroups based on adjusted hazard ratios (AHRs), weighted by these prognos

SUBMITTER: Guo Y 

PROVIDER: S-EPMC12401677 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature