The gut microbiome and metabolome in children with a first febrile urinary tract infection: a pilot study.

ABSTRACT:

Background

Urinary tract infection (UTI) is a common bacterial infection in the pediatric population. Febrile urinary tract infection (fUTI) can lead to severe complications such as urosepsis as well as kidney scarring, chronic kidney disease, and systemic hypertension. Recent research supports the hypothesis that dysbiosis of the microbiome may play a role in the pathogenesis and development of fUTI in infants. Our main aim was to compare the shift in gut microbiota composition between children with the first fUTI and controls.

Methods

We conducted an observational study with 17 children with the first fUTI compared to 18 healthy controls. We performed analysis of the gastrointestinal microbiome and measurements of metabolites in stool and urine.

Results

In the gut m

SUBMITTER: Pitekova B 

PROVIDER: S-EPMC12402013 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature