Germline DNA Damage Repair Variants and Prognosis of Patients with High-Risk or Metastatic Prostate Cancer.

ABSTRACT:

Purpose

Deleterious germline variants in certain DNA repair genes are risk factors for developing aggressive prostate cancer. The objective was to quantify their prognostic impact after prostate cancer diagnosis.

Experimental design

Men with prostate cancer, predominantly of European ancestry, were included from four cohorts with long-term follow-up. Pathogenic or likely pathogenic germline variants in 26 DNA repair genes were assessed in relation to metastasis-free survival in high-risk localized prostate cancer and to overall survival in metastatic castration-sensitive prostate cancer (mCSPC) and metastatic castration-resistant prostate cancer (mCRPC).

Results

Among 3,525 patients initially diagnosed with nonmetastatic prostate cancer, 2,594 had high-risk localized

SUBMITTER: Stopsack KH 

PROVIDER: S-EPMC12407385 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature