Approaches for the treatment of perforated peptic ulcers: a network meta-analysis of randomized controlled trials.

ABSTRACT:

Purpose

This network meta-analysis (NMA) aims to evaluate surgical and alternative treatment strategies for perforated peptic ulcers (PPU) with respect to mortality and other clinically relevant outcomes.

Methods

An NMA was conducted in accordance with PRISMA guidelines to assess treatment approaches for PPU. Randomized controlled trials (RCT) were identified through systematic searches of PubMed/MEDLINE, Cochrane Library, Embase, CINAHL, ClinicalTrials.gov, and ICTRP databases. Outcomes were analyzed using standardized mean differences (SMDs) for continuous data and odds ratios (ORs) for binary data, both presented with 95% confidence intervals (CI) in a network meta-analysis framework.

Results

Sixteen studies comprising 1,259 patients were included in this NMA. The

SUBMITTER: Wadewitz E 

PROVIDER: S-EPMC12413338 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature