Effect of education on endometriosis and mediating effects: a mendelian randomization study.

ABSTRACT:

Objectives

To assess the potential impact of years of education, which serves as a measure of socioeconomic inequality, on the occurrence of endometriosis, and to quantify the potential influence of modifiable factors as mediators.

Methods

The study used SNPs as genetic tools for genetic association. Analysis using 2-sample univariate and multivariate Mendelian randomization methods. Primary analyses were performed using an inverse variance weighted MR method. Data were obtained from publicly available genome-wide association studies (GWAS) from European populations. Data for ending endometriosis were obtained from the Neale lab.

Results

Each SD increase in years of education (4.2 years) has a protective effect on endometriosis (OR 0.9975; 95% CI 0.9958-0.9951). For i

SUBMITTER: Jin L 

PROVIDER: S-EPMC12414883 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature