Comprehensive analysis of the systemic immune landscape across breast cancer subtypes and disease stages.

ABSTRACT:

Background

Breast cancer is a systemic disease, yet the impact of tumor molecular subtype and disease stage on the systemic immune landscape remains poorly understood. In this study, we comprehensively analyzed the systemic immune landscape in a large cohort of breast cancer patients, encompassing all molecular subtypes and disease stages, alongside a control group of healthy donors.

Materials and methods

Using multi-parameter flow cytometry, we assessed the abundance, phenotype, and activation status of diverse innate and adaptive immune cell populations across peripheral blood samples from 355 breast cancer patients and 65 healthy donors. Analyzing all blood samples immediately after collection enabled analysis of often overlooked, but highly abundant granulocyte populatio

SUBMITTER: Bakker NAM 

PROVIDER: S-EPMC12415084 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature