Coordinated actions of NLR-assembled and glutamate receptor-like calcium channels in plant effector-triggered immunity.

ABSTRACT: The plant immune system utilizes nucleotide-binding/leucine-rich repeat (NLR) proteins to detect pathogen virulence factors (effectors) inside host cells and transduce recognition to rapid defense. In dicotyledenous plants, pathogen activated Toll-like/interleukin-1 receptor-containing NLRs (TNLs) establish a signaling network of enhanced susceptibility 1 (EDS1)-family dimers with RPW8-type coiled-coil (CC_R) domain NLRs (RNLs) to stimulate transcriptional reprogramming leading to host cell death and pathogen restriction. Evidence suggests that TNL- and EDS1-activated RNLs function as oligomeric Ca²⁺ permeable ion channels at the plasma membrane. However, the downstream processes for immunity execution are poorly understood. Here, we studied pathogen effector-triggered

SUBMITTER: Wang J 

PROVIDER: S-EPMC12415192 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature