Alteration in Amino Acid Composition and Configuration in Cyanobacterial Peptides Affects Biological Activity.

ABSTRACT: Cyanobacterial blooms are a significant environmental concern due to their production of toxic metabolites with potential impacts on ecosystem and human health. Microcystin-LR and microcystin congeners are a major concern with respect to human exposure and intoxication, but there are hundreds of characterized cyanobacterial peptides and metabolites that are of interest for their environmental impact in a variety of classes such as cyanopeptolins/micropeptins, microviridins, microginins, and anabaenopeptins. In this study, we report the isolation and characterization of new micropeptins (1-4), a new ferintoic acid (5) a new microginin (6), and three new microviridins (7-9) from a cyanobacterial bloom sample. The new micropeptins, in particular, exhibited unpreced

SUBMITTER: Xia R 

PROVIDER: S-EPMC12418302 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature