Identification of Functional Cellular Markers Related to Human Health, Frailty and Chronological Age.

ABSTRACT: Aging leads to a decline in physiological reserves, an increase in age-related diseases, reduced functional ability and a shortened healthspan. While molecular markers of chronological aging exist, their link to general health and intrinsic capacity (IC), a composite measure of physical and mental capacities, remains unclear. This study integrates the WHO's Healthy Aging framework with geroscience to explore fibroblasts as indicators of health. We assessed primary skin fibroblasts from 133 individuals aged 20-96, evaluating their ability to maintain tissue structure, modulate immune responses and regulate metabolism (SIM functions). By combining functional and molecular analyses, we investigated the relationship between fibroblast performance, chronological age and IC. Our results demonstr

SUBMITTER: Brodeau C 

PROVIDER: S-EPMC12419852 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature