Dataset Information

Dissecting the Causal Association Between Bulimia Nervosa and Structural Brain Abnormalities: A Two-Sample Bidirectional Mendelian Randomization Study.

ABSTRACT:

Background

Diverse correlations between structural brain abnormalities and the clinical feature of bulimia nervosa (BN) have been identified in previous observational studies.

Objective

To explore the bidirectional causality between BN and brain structural magnetic resonance imaging (MRI) phenotypes.

Methods

Genome-wide association studies (GWAS) of 2441 participants identified genetic variants associated with disordered eating and predicted BN, whereas UK Biobank 3D-T1 MRI data were used to analyze brain structural phenotypes. A bidirectional two-sample Mendelian randomization (MR) approach was used to investigate the causal relationships between BN and brain structural traits.