Sustainable Extraction of the Tetrahydropalmatine Alkaloid from <i>Stephania rotunda</i> Lour. Tubers Using Eco-Friendly Solvent Systems.

ABSTRACT: Tetrahydropalmatine (THP) is the major bioactive alkaloid in Stephania rotunda Lour. (Menispermaceae) with well-known pharmacological properties, such as antiaddiction, antitumor, and neuroprotective activities. In this study, a novel ultrasonic-assisted extraction method for the sustainable extraction of the tetrahydropalmatine alkaloid from S. rotunda Lour. tubers was developed and optimized. The study reports also the development and validation of an HPLC-PDA analytical method intended for the quantification of THP in S. rotunda medicinal plant accompanied by a rapid and straightforward sample preparation procedure. A set of environmentally friendly and human-safe solvents was systematically evaluated for their extraction yield of THP, and the response surface metho

SUBMITTER: Nguyen KV 

PROVIDER: S-EPMC12423853 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature