Immunosenescence phenotypes and prognostic significance of CD8 + CD28- T cells in AIDS-related non-Hodgkin lymphoma.

ABSTRACT:

Background

AIDS-related non-Hodgkin lymphoma (AR-NHL), a leading malignancy among people living with HIV (PLWH), may not receive standard intensive curative therapies as the general population due to immune deficiency concerns, even in the combined antiretroviral therapy (cART) and immunochemotherapy era. Thus, a comprehensive understanding of T-cell subsets landscapes is urgently needed to grasp the complex and dynamic role of the immune system in AR-NHL patients' survival.

Materials and methods

This longitudinal cohort study enrolled 31 de novo adult AR-NHL patients and 52 HIV-negative NHL controls. Multi-color flow cytometry profiled peripheral blood immunophenotypes at baseline and during immunochemotherapy. Univariate and multivariate Cox regression analyses eval

SUBMITTER: Kang Z 

PROVIDER: S-EPMC12427475 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature