Intervertebral disc degeneration of the lumbar spine assessed in vivo with 3T magnetic resonance tomoelastography.

ABSTRACT:

Introduction

Assessment of intervertebral disc (IVD) degeneration on conventional magnetic resonance imaging (MRI) is limited by large inter-reader variability and lack of stratification in clinical trials and their assessment of treatment responses. Therefore, we aimed to introduce and diagnostically validate multifrequency magnetic resonance elastography (MRE) with tomoelastography processing for the assessment of lumbar IVD degeneration in healthy volunteers and patients with low back pain.

Methods

In this prospective single-center study, 60 participants (30 volunteers without low back pain and 30 patients with low back pain, 41 ± 17 years, body mass index 23.9 ± 3.7 kg/m², 25 women) underwent multifrequency MRE using vibration frequencies from 40 to 70 Hz usin

SUBMITTER: Reiter R 

PROVIDER: S-EPMC12429253 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature