APOE genotype-dependent differences in human astrocytic energy metabolism.

ABSTRACT:

Introduction

The main genetic risk factor for Alzheimer's disease (AD) is the presence of the apolipoprotein E4 (APOE4) allele. While APOE4 increases the risk of developing AD, the APOE2 allele is protective and APOE3 is risk-neutral. In the brain, APOE is primarily expressed by astrocytes and plays a key role in various processes including cholesterol and lipid transport, neuronal growth, synaptic plasticity, immune response and energy metabolism. Disruptions in brain energy metabolism are considered a major contributor to AD pathophysiology, raising a key question about how different APOE isoforms affect the energy metabolism of human astrocytes.

Methods

In this study, we generated astrocytes (iAstrocytes) from APOE-isogenic human induced

SUBMITTER: Budny V 

PROVIDER: S-EPMC12434100 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature