Genome-wide pleiotropy analysis of longitudinal blood pressure and harmonized cognitive performance measures.

ABSTRACT:

Introduction

Identifying pleiotropy for blood pressure (BP) and cognitive performance measures may indicate mechanistic links between hypertension and Alzheimer's disease (AD).

Methods

We performed a pleiotropy genome-wide association study (GWAS) for paired measures of systolic, diastolic, pulse, and mean arterial pressure with memory, executive function, and language scores using 116,075 exam data from 25,726 participants in clinic-based and prospective cohorts. Significant findings were evaluated by Bayesian colocalization and differential gene expression in brain tissue from pathologically confirmed AD cases with and without clinical symptoms.

Results

Genome-wide significant pleiotropy for BP and cognitive performance with JPH2, GATA3, PAX2, LOC105371656, and SUFU

SUBMITTER: Kang M 

PROVIDER: S-EPMC12434708 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature