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Lower non-invasive estimated P<sub>mus</sub> predicts extubation failure in mechanically ventilated ICU patients.

ABSTRACT: We evaluated whether non-invasive estimated inspiratory muscle pressure (Pmus) predicts extubation outcomes in ICU patients. Estimated Pmus, reflecting the pressure generated by respiratory muscles, was measured before and after the spontaneous breathing trial (SBT). Lower pre-SBT estimated Pmus (<4.1 cmH₂O) and post-SBT (<4.4 cmH₂O) were associated with extubation failure (AUC ≈ 0.73). P0.1 and dynamic transpulmonary pressure (PL,dyn) showed no significant association. Estimated Pmus offers a simple bedside method to assess inspiratory muscle strength and may help identify patients at risk of extubation failure. Further multicenter studies are needed to validate these findings.

SUBMITTER: Muller G 

PROVIDER: S-EPMC12440903 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature

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Lower non-invasive estimated P&lt;sub&gt;mus&lt;/sub&gt; predicts extubation failure in mechanically ventilated ICU patients.

Müller Graziela G   Zocoli Manoela Bonato MB   Magnante Jéssica J   Zamprogna Geovana Teo GT   do Nascimento Silvano Altair SA   Rático Gustavo Bruno GB   Goligher Ewan C EC   Baptistella Antuani Rafael AR  

Journal of the Intensive Care Society 20250916 4

We evaluated whether non-invasive estimated inspiratory muscle pressure (P<sub>mus</sub>) predicts extubation outcomes in ICU patients. Estimated P<sub>mus</sub>, reflecting the pressure generated by respiratory muscles, was measured before and after the spontaneous breathing trial (SBT). Lower pre-SBT estimated P<sub>mus</sub> (<4.1 cmH₂O) and post-SBT (<4.4 cmH₂O) were associated with extubation failure (AUC ≈ 0.73). P0.1 and dynamic transpulmonary pressure (P<sub>L,dyn</sub>) showed no signif  ...[more]

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