Estimands for Clinical Effectiveness of Risk-Reducing Early Salpingectomy in Women With High Risk of Ovarian Cancer.

ABSTRACT:

Importance

Risk-reducing early-salpingectomy (RRES) and delayed oophorectomy (DO) is a novel 2-stage alternative prevention strategy to risk-reducing salpingo-oophorectomy (RRSO) that avoids detrimental consequences of premature menopause. However, direct data on the clinical effectiveness for ovarian cancer (OC) risk reduction are lacking.

Objective

To explore how to define clinical effectiveness from prospective cohort studies using the estimand framework and sample size requirements.

Design, setting, and participants

In this comparative effectiveness research study, estimand and analysis options were considered to evaluate the clinical effectiveness of RRES with DO by extending the UK PROTECTOR cohort study, a multicenter, prospective, observational, national cohor

SUBMITTER: Sia J 

PROVIDER: S-EPMC12441877 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature