Longitudinal relationships between changes in post-COVID mental fatigue and neuropsychiatric symptoms across distinct recovery trajectories.

ABSTRACT:

Background

Persistent fatigue, often accompanied by neuropsychiatric symptoms (e.g., cognitive impairment, sleep disorders, depression, anxiety, and PTSD), commonly referred to as "long COVID". Fatigue is multidimensional, comprising physical, psychological, and situational components. However, the relationships between these fatigue dimensions and co-occurring neuropsychiatric symptoms remain unclear. This study aimed to (1) examine the time-varying characteristics of post-COVID fatigue and (2) determine whether specific fatigue dimensions uniquely affect neuropsychiatric symptoms in long COVID.

Methods

We analyzed neuropsychiatric assessments from 233 individuals at 1 and 3 months post-infection using Canonical Correlation Analysis (CCA). Participants were categorized into

SUBMITTER: Bao W 

PROVIDER: S-EPMC12443899 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature