Feeding state-specific hormonal tuning of neural circuit modulation.

ABSTRACT: Studies of hormone influences on neural circuits and behavior have primarily focused on the manipulation of individual hormones. Here, we examine the influence of behavioral (feeding) state-specific hormonal environments on the gastric mill (chewing) circuit configured by the neuropeptide Gly¹-SIFamide (G-SIFamide) in the isolated Cancer borealis stomatogastric ganglion (STG). The G-SIFamide-activated gastric mill rhythm, which is similar to that driven by the G-SIFamidergic projection neuron modulatory commissural neuron 5 (MCN5), is distinguished from other gastric mill rhythms by the presence of rhythmic, prolonged inferior cardiac (IC) neuron bursts and associated interruptions of the pyloric rhythm. Applying 1 µM G-SIFamide in saline only occasionally activated the g

SUBMITTER: Fickling LJ 

PROVIDER: S-EPMC12450063 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature