Mechanism of Tiaogeng decoction in a cognitive dysfunction mouse model.

ABSTRACT:

Objective

To explore the mechanism of action of Tiaogeng decoction (, TG) in alleviating oxidative stress damage in the hippocampus of a mouse model of cognitive impairment.

Methods

Amyloid precursor protein/presenilin-1 (APP/PS1) transgenic female mice were randomly divided into model, estradiol valerate, low-, medium-, and high-dose TG groups, female C57 mice were used as the control group (n = 12/group). After 12 weeks of treatment, the behavior of mice was tested with the Morris water maze, and brain tissue samples were collected, and changes in hippocampal neurons were observed using electron microscopy. The deposition of beta-amyloid protein (Aβ) amyloid plaques in the hippocampus was determined by light microscopy. Aβ1-42 protein levels were detected through im

SUBMITTER: Shuang NI 

PROVIDER: S-EPMC12453984 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature