Longitudinal evaluation of serum cholinesterase benefits prognosis surveillance of common types of human cancer.

ABSTRACT:

Background

Existing literature on serum cholinesterase (ChE) in cancer prognosis have predominantly evaluated preoperative levels, ignoring serial ChE measurements during postoperative follow-up.

Methods

5925 patients undergoing curative resection for stage I-III non-small cell lung cancer (NSCLC), colorectal cancer (CRC), and gastric cancer (GC) were retrospectively included. Patients were divided into persistently normal, normalized, lowered and persistently low perioperative ChE patterns, as well as longitudinal ChE trajectories identified by the latent class growth mixed model (LCGMM). The associations of ChE dynamic changes with overall survival (OS) and recurrence-free survival (RFS) were evaluated.

Results

Postoperative ChE emerged as an independent prognostic

SUBMITTER: Li C 

PROVIDER: S-EPMC12454652 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature