Glial Fibrillary Acidic Protein Astrocytopathy Based on a Two-Center Chinese Cohort Study.

ABSTRACT:

Objective

Glial fibrillary acidic protein astrocytopathy (GFAP-A) is a recently defined nosological form belonging to the class of autoimmune inflammatory disorders affecting the central nervous system (CNS). Here, we report the clinical and MRI characteristics, treatment, and prognosis of a GFAP-A cohort from two centers in China.

Methods

We retrospectively analyzed the data from 38 adult patients with positive GFAP antibodies and diagnosed as GFAP-A between June 2019 and September 2024. Clinical features, semiquantitative antibody test results, MRI features, treatment approaches, and prognosis were collected.

Results

Among the 38 patients, 24 were male, and the median age at disease onset was 49.5 years. The clinical phenotype included encephalomyelitis (28.9%), mye

SUBMITTER: Wu T 

PROVIDER: S-EPMC12455873 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature