The Integrated Cellular and Molecular Landscape of Autoimmunity.

ABSTRACT: We performed a large-scale immunogenomic analysis of ~13,000 transcriptomic profiles from 10 autoimmune diseases, integrating publicly available datasets from both blood and tissue. Using meta-analysis, we identified core immune mechanisms underlying autoimmunity, including strong interferon responses, inflammation, and adaptive immune suppression, alongside disease-specific signatures. To enhance biological interpretability, we derived higher-order immune features - such as cell type proportions, cytokine levels, pathway activity, transcription factor regulation, and miRNA activity - and organized them into 15 coherent immune modules. These modules enabled systematic cross-disease comparisons, revealing shared and distinct immunopathological patterns. The inflammation module, in particula

SUBMITTER: Appierdo R 

PROVIDER: S-EPMC12458282 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature