Identification of novel H2A histone variants across diverse clades of algae.

ABSTRACT:

Background

Histones are among the most conserved proteins in eukaryotes. They not only ensure DNA compaction in the nucleus but also participate in epigenetic regulation of gene expression. These key epigenetic players are divided into replication-coupled histones, expressed during the S-phase, and replication-independent variants, expressed throughout the cell cycle. Compared with other core histones, H2A proteins exhibit a high level of variability but the characterization of algal H2A variants remains very limited.

Results

In this study, we exploit genome and transcriptome data from 22 species to identify H2A variants in brown seaweeds. Combined analyses of phylogenetic data, synteny and protein motifs enable us to reveal the presence of new H2A variants as well as their

SUBMITTER: Rousselot E 

PROVIDER: S-EPMC12459048 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature