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Cu-diamine ligand-controlled asymmetric Henry reactions and their application in concise total syntheses of linezolid and rivaroxaban.

ABSTRACT: A Cu-bis(sulfonamide)-diamine complex catalytic system was exploited in asymmetric Henry reactions to construct versatile chiral nitroalcohols with high enantioselectivity from carbamate-acetaldehydes and nitromethane. This elegant approach was further implemented to complete the asymmetric total syntheses of a series of oxazolidone skeleton drugs, such as linezolid (antibiotic) and rivaroxaban (anti-coagulant), in a concise and efficient way.

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12459656 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature

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Cu-diamine ligand-controlled asymmetric Henry reactions and their application in concise total syntheses of linezolid and rivaroxaban.

Zhang Yiwei Y   Xiao Wei W  

RSC advances 20250924 42

A Cu-bis(sulfonamide)-diamine complex catalytic system was exploited in asymmetric Henry reactions to construct versatile chiral nitroalcohols with high enantioselectivity from carbamate-acetaldehydes and nitromethane. This elegant approach was further implemented to complete the asymmetric total syntheses of a series of oxazolidone skeleton drugs, such as linezolid (antibiotic) and rivaroxaban (anti-coagulant), in a concise and efficient way. ...[more]

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