Expanding the cytokine receptor alphabet reprograms T cells into diverse states.

ABSTRACT: T cells respond to cytokines through receptor dimers that have been selected over the course of evolution to activate canonical JAK-STAT signalling and gene expression programs¹. However, the potential combinatorial diversity of JAK-STAT receptor pairings can be expanded by exploring the untapped biology of alternative non-natural pairings. Here we exploited the common γ chain (γ_c) receptor as a shared signalling hub on T cells and enforced the expression of both natural and non-natural heterodimeric JAK-STAT receptor pairings using an orthogonal cytokine receptor platform^2-4 to expand the γ_c signalling code. We tested receptors from γ_c cytokines as well as interferon, IL-10 and homodimeric receptor families that do not normally pair w

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC12460165 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature