Seroprevalence of antibodies to <i>Plasmodium falciparum</i> transmission-blocking target proteins Pfs230D1M and Pfs48/45 in Tanzanian populations of diverse malaria transmission intensity.

ABSTRACT: Transmission-blocking vaccines are among the novel tools under development for malaria control and elimination. Understanding the human immune response to the sexual stages of Plasmodium falciparum is essential for progressing transmission-blocking vaccine development. A serosurvey was conducted in Tanzania, from May to August 2022 among 290 participants, consisting of 114 children (5-12 years), 44 adolescents (13-17 years), and 132 adults (18-45 years). The participants were tested for malaria parasites using quantitative polymerase chain reaction, and standardized enzyme-linked immunosorbent assays were performed to detect the presence of IgG antibodies against transmission-blocking target antigens-Pfs230D1M, Pfs48/45, and Pfs25. A set of 10 plasma samples that were reactive to Pf

SUBMITTER: Mulamba C 

PROVIDER: S-EPMC12460233 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature