Integrated Transcriptome and Metabolomics Analyses Show MYC as a Potential Therapeutic Target for Behcet's Uveitis.

ABSTRACT: Behçet's uveitis (BU), characterized by recurrent bilateral panuveitis, is a severe manifestation of Behcet's disease (BD). However, disease-specific metabolic alterations in BU remain largely unknown. Here, untargeted metabolomics and single-cell RNA sequencing (scRNA-seq) are performed in patients with BU and healthy controls (HC). scRNA-seq data of experimental autoimmune uveitis (EAU) mice are also incorporated. The data showed an altered metabolic profile, characterized by upregulated glycolysis in BU. MYC is predicted to be a hub molecule regulating glycolysis and T cell response. Notably, it is discovered that the expression level of MYC is higher in BU compare to HC and may reflect the treatment response of BU disease. Correspondingly, the scRNA-seq data of EAU mice also reveal hig

SUBMITTER: Li H 

PROVIDER: S-EPMC12463086 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature