Developing a Simple Scoring System on CT Findings for Predicting Treatment Failure in <i>Mycobacterium avium</i> Complex Pulmonary Disease: The BCD (Bronchiectasis and Cavity Distribution) Score.

ABSTRACT:

Background

Optimal timing for treatment initiation in Mycobacterium avium complex pulmonary disease (MAC-PD) remains unclear due to lack of established rules for predicting treatment response.

Methods

A retrospective observational study was conducted to develop a prediction model for treatment failure at 2 Japanese university hospitals between 2012 and 2023. Participants were 135 patients with MAC-PD who received macrolides and ethambutol-containing regimens over 1 year. Treatment failure was defined as nonachievement culture conversion at 1 year. We selected model components as cavity (categorized by diameter) and bronchiectasis (categorized by modified Reiff score) on pretreatment computed tomography. Their combinations of each category were scored based on number o

SUBMITTER: Hayashi M 

PROVIDER: S-EPMC12465108 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature