Cryptococcus neoformans tibial osteomyelitis in an immunocompetent host: a case diagnosed by tNGS.

ABSTRACT:

Background

Cryptococcus neoformansis widely distributed in nature and primarily causes infections in various parts of the body through inhalation into the lungs. While C.neoformans infection predominantly occurs in immunocompromised individuals, there has been a significant increase in reports among immunocompetent hosts in recent years. Although the lungs and central nervous system constitute the most common sites of infection, cryptococcal osteomyelitis remains exceptionally rare and is typically associated with disseminated disease in immunodeficient patients. Herein, we present a rare case of isolated tibial cryptococcal osteomyelitis in an immunocompetent patient.

Case presentation

We report a case of a 64-year-old female who presented with pain, swelling, and increased

SUBMITTER: Qin W 

PROVIDER: S-EPMC12465621 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature