A two-site collaborative study of electrical impedance myography for evaluation of disease progression in murine Duchenne muscular dystrophy models.

ABSTRACT: Accessibility to outcome measures that reliably assess disease pathology in preclinical studies are vital, especially for rare disorders such as Duchenne muscular dystrophy (DMD). The non-invasive technique of electrical impedance myography (EIM) has shown potential as an outcome measure in patients and mouse models of neuromuscular disorders. However, these preclinical observations have been limited to a single site. Here, we performed a longitudinal, parallel two-site study to assess the potential of EIM as an outcome measure by using two DMD mouse models - mdx mice on a C57BL/10ScSn/J or DBA/2J genetic background - differing in disease severity, and being hypertrophic and atrophic, respectively, over a ten-month period, in which mice were evaluated monthly. We found that longitudinally

SUBMITTER: Mantuano P 

PROVIDER: S-EPMC12475182 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature